Pathophysiology of Lung Cancer

Pathophysiology of lung cancer development is complex and incompletely understood. Genes influence the pathogenesis of cancer to generate proteins involved in development and cell differentiation, apoptosis, tumor progression, the processes of cell cycle, angiogenesis and immune regulation. Exposure of these mechanisms should lead to new means of risk stratification, early detection, prevention and treatment.

Cancer is primarily a disease of the regulation of tissue growth. A normal cell, its turned into a cancer cell because a cell transformed by mutation and genetic changes that cause the loss of whole chromosomes and affected the outcome of a single DNA nucleotide.

Pathophysiology of lung cancer development is complex and not understood, it will be a book to describe how the mechanisms of the pathophysiology of lung cancer process happened.


Cigarette smoking is responsible for approximately 30% of cancer deaths. Smoking is responsible for 85% of cases of lung cancer in men and 75% in women. There are about 38 million former smokers and 50 million cigarette smokers in the United States. Smoking rates are higher among blacks, blue collar workers and less educated people.

More than 140,000 lives lost to cancer every year due to consumption of snuff. All cancers caused by cigarette smoking could be avoided. It is expected that public education, smoking cessation programs, and efforts to remove carcinogens in the workplace affect the future incidence of new cases of lung cancer.

As preventive measures continue, the refinement in the diagnosis and treatment of cancer forward. The recognition of any of the warning signs of cancer and the subsequent seven quick action could lead to earlier detection and an opportunity for 3 - and 5-year survival rates improve.

With medical advances and research clinics have grown beyond addressing only the physical needs of the patient to include important issues such as employment needs and insurance and psychosocial needs of both the patient and family, as learn to live with cancer.


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